GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4409766 | 1 | rs4409766 | chr10:104616663 | AS3MT | chr10:104613967-104661653:+ | -0.27 | -3.83 | 0.000145 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs4409766 | 1 | rs4409766 | chr10:104616663 | C10orf26 | chr10:104503727-104591851:+ | -0.19 | -3.37 | 0.00082 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs4409766 | 1 | rs4409766 | chr10:104616663 | INA | chr10:105036920-105050106:+ | -0.24 | -3.36 | 0.000834 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs4409766 | 1 | rs4409766 | chr10:104616663 | SFXN2 | chr10:104474298-104498946:+ | -0.32 | -3.93 | 9.77E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THCA | cis | rs1978968 | 1 | rs4410378 | chr22:18451391 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -4.07 | 5.46E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs7552404 | 1 | rs441109 | chr1:76120430 | MSH4 | chr1:76262630-76378923:+ | -0.25 | -4.24 | 2.73E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs9392653 | 1 | rs441144 | chr6:5073292 | LYRM4 | chr6:5108654-5261168:- | 0.15 | 3.59 | 0.000368 | Venous thromboembolism (SNP x SNP interaction) |
| THCA | cis | rs3925075 | 1 | rs4411512 | chr16:31347445 | HSD3B7 | chr16:30996519-31000473:+ | -0.16 | -3.93 | 9.81E-5 | IgA nephropathy |
| THCA | cis | rs4438470 | 1 | rs4416207 | chr2:229016839 | SPHKAP | chr2:228844670-229046361:- | -0.22 | -3.35 | 0.00086 | Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer |
| THCA | cis | rs1124376 | 1 | rs4417886 | chr3:20108511 | EFHB | chr3:19920968-19988501:- | 0.24 | 3.47 | 0.000563 | Bipolar disorder and schizophrenia |
| THCA | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.7 | 4.92E-32 | Height |
| THCA | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.31 | 6.53E-10 | Height |
| THCA | cis | rs441810 | 1 | rs441810 | chr21:42698907 | FAM3B | chr21:42676177-42729654:+ | 0.49 | 7.48 | 3.59E-13 | Elevated serum carcinoembryonic antigen levels;Tumor biomarkers |
| THCA | cis | rs9346353 | 1 | rs4418153 | chr6:70512679 | LMBRD1 | chr6:70385751-70506888:- | -0.09 | -3.36 | 0.00085 | Sleep duration |
| THCA | cis | rs4420500 | 1 | rs4420500 | chr15:78962964 | CHRNA5 | chr15:78857906-78886458:+ | -0.19 | -3.53 | 0.000449 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |